• 靶点：
• AQP7

• 简介：
• >>PPAR signaling pathway;>>Regulation of lipolysis in adipocytes

• 基因名称：
• AQP7 AQP7L AQP9

• 蛋白名称：
• AQP7

• Human Gene Id：
• 364

• Human Swiss Prot No：
• O14520

• Mouse Gene Id：
• 11832

• Mouse Swiss Prot No：
• O54794

• Rat Gene Id：
• 29171

• Rat Swiss Prot No：
• P56403

• 免疫原：
• Synthesized peptide derived from human AQP7 AA range: 136-186

• 特异性：
• This antibody detects endogenous levels of AQP7 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 38kD

• 背景：
• This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015],

• 功能：
• domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).,function:Forms a channel for water and glycerol.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Cytoplasm, cell cortex . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Lipid droplet . Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (PubMed:27832861). .

• 组织表达：
• Detected in the sperm head (at protein level) (PubMed:28042826). Detected in white adipose tissue (PubMed:9405233).

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