• 靶点：
• NALP4

• 简介：
• >>Pathogenic Escherichia coli infection

• 基因名称：
• NLRP4 NALP4 PAN2 PYPAF4 RNH2

• 蛋白名称：
• NALP4

• Human Gene Id：
• 147945

• Human Swiss Prot No：
• Q96MN2

• 免疫原：
• Synthesized peptide derived from human NALP4 AA range: 307-357

• 特异性：
• This antibody detects endogenous levels of NALP4 at Human

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 109kD

• 背景：
• NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008],

• 功能：
• alternative products:Experimental confirmation may be lacking for some isoforms,function:May be involved in inflammation.,sequence caution:Translated as Gln.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,

• 细胞定位：
• cytosol,extracellular exosome,

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