FXL12 rabbit pAb

    • 货号:YT6954
    • 应用:WB
    • 种属:Human;Mouse
      • 靶点:
      • FXL12
      • 基因名称:
      • FBXL12 FBL12
      • 蛋白名称:
      • FXL12
      • Human Swiss Prot No:
      • Q9NXK8
      • Mouse Swiss Prot No:
      • Q9EPX5
      • 免疫原:
      • Synthesized peptide derived from human FXL12 AA range: 8-58
      • 特异性:
      • This antibody detects endogenous levels of FXL12 at Human/Mouse
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量:
      • 36kD
      • 背景:
      • Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008],
      • 功能:
      • function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with SKP1A and CUL1.,
      • 细胞定位:
      • ubiquitin ligase complex,cytoplasm,integral component of membrane,
      • 产品图片
      • Western blot analysis of lysates from Jurkat cells, primary antibody was diluted at 1:1000, 4°over night