UBA3 rabbit pAb

    • 货号：YT6896
    • 应用：WB
    • 种属：Human;Mouse;Rat
      • 靶点：
      • UBA3
      • 简介：
      • >>Ubiquitin mediated proteolysis
      • 基因名称：
      • UBA3 UBE1C
      • 蛋白名称：
      • UBA3
      • Human Gene Id：
      • 9039
      • Human Swiss Prot No：
      • Q8TBC4
      • Mouse Swiss Prot No：
      • Q8C878
      • 免疫原：
      • Synthesized peptide derived from human UBA3 AA range: 105-155
      • 特异性：
      • This antibody detects endogenous levels of UBA3 at Human/Mouse/Rat
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1：500-2000
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量：
      • 51kD
      • 背景：
      • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
      • 功能：
      • enzyme regulation:Binding of TP53BP2 to the regulatory subunit NAE1 decreases activity.,function:Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.,miscellaneous:Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.,pathway:Protein modification; protein neddylation.,similarity:Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.,subunit:Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand.,tissue specificity:Ubiquitousl
      • 细胞定位：
      • nucleus,cytosol,
      • 组织表达：
      • Ubiquitously expressed.
      • 产品图片
      • Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night

      相关报价

      • 货号：
      • YT6896
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-09-03
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