• 靶点：
• C1GLT

• 简介：
• >>Mucin type O-glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways

• 基因名称：
• C1GALT1

• 蛋白名称：
• C1GLT

• Human Gene Id：
• 56913

• Human Swiss Prot No：
• Q9NS00

• Mouse Gene Id：
• 94192

• Mouse Swiss Prot No：
• Q9JJ06

• Rat Gene Id：
• 65044

• Rat Swiss Prot No：
• Q9JJ05

• 免疫原：
• Synthesized peptide derived from human C1GLT AA range: 102-152

• 特异性：
• This antibody detects endogenous levels of C1GLT at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 40kD

• 背景：
• The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010],

• 功能：
• catalytic activity:UDP-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.,cofactor:Magnesium.,disease:Defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy (IgAN). IgAN is the most common primary glomerulonephritis, which is partly due to aberrant or incomplete galactosylation of IgA1 molecules.,function:Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.,online information:Core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.,

• 细胞定位：
• Membrane ; Single-pass type II membrane protein .

• 组织表达：
• Widely expressed. Highly expressed in kidney, heart, placenta and liver.

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