• 靶点：
• FACR1

• 简介：
• >>Peroxisome

• 基因名称：
• FAR1 MLSTD2 UNQ2423/PRO4981

• 蛋白名称：
• FACR1

• Human Gene Id：
• 84188

• Human Swiss Prot No：
• Q8WVX9

• Mouse Gene Id：
• 67420

• Mouse Swiss Prot No：
• Q922J9

• Rat Gene Id：
• 293173

• Rat Swiss Prot No：
• Q66H50

• 免疫原：
• Synthesized peptide derived from human FACR1 AA range: 135-185

• 特异性：
• This antibody detects endogenous levels of FACR1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 57kD

• 背景：
• The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015],

• 功能：
• catalytic activity:Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP(+).,function:Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols.,similarity:Belongs to the fatty acyl-CoA reductase family.,

• 细胞定位：
• Peroxisome membrane ; Single-pass membrane protein .

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