• 靶点：
• MLXPL

• 简介：
• >>Insulin resistance;>>Non-alcoholic fatty liver disease

• 基因名称：
• MLXIPL BHLHD14 MIO WBSCR14

• 蛋白名称：
• MLXPL

• Human Gene Id：
• 51085

• Human Swiss Prot No：
• Q9NP71

• Mouse Gene Id：
• 58805

• Mouse Swiss Prot No：
• Q99MZ3

• Rat Gene Id：
• 171078

• Rat Swiss Prot No：
• Q8VIP2

• 免疫原：
• Synthesized peptide derived from human MLXPL AA range: 303-353

• 特异性：
• This antibody detects endogenous levels of MLXPL at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 94kD

• 背景：
• This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

• 功能：
• disease:Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Binds DNA as a heterodimer with TCFL4/MLX.,tissue specificity:Expressed in liver, heart, kidney, cerebellum and intestinal tissues.,

• 细胞定位：
• Nucleus.

• 组织表达：
• Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

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