• 靶点：
• GFPT1

• 简介：
• >>Alanine, aspartate and glutamate metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of nucleotide sugars;>>Insulin resistance;>>Diabetic cardiomyopathy

• 基因名称：
• GFPT1 GFAT GFPT

• 蛋白名称：
• GFPT1

• Human Gene Id：
• 2673

• Human Swiss Prot No：
• Q06210

• Mouse Gene Id：
• 14583

• Mouse Swiss Prot No：
• P47856

• Rat Gene Id：
• 297417

• Rat Swiss Prot No：
• P82808

• 免疫原：
• Synthesized peptide derived from human GFPT1 AA range: 198-248

• 特异性：
• This antibody detects endogenous levels of GFPT1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 77kD

• 背景：
• This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008],

• 功能：
• catalytic activity:L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.,function:Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.,pathway:Nucleotide-sugar biosynthesis; UDP-N-acetyl-D-glucosamine biosynthesis; D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.,similarity:Contains 1 glutamine amidotransferase type-2 domain.,similarity:Contains 2 SIS domains.,subunit:Homotetramer .,tissue specificity:Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.,

• 细胞定位：
• cytosol,extracellular exosome,

• 组织表达：
• Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.

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