• 靶点：
• DCK

• 简介：
• >>Purine metabolism;>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism

• 基因名称：
• DCK

• 蛋白名称：
• DCK

• Human Gene Id：
• 1633

• Human Swiss Prot No：
• P27707

• Mouse Gene Id：
• 13178

• Mouse Swiss Prot No：
• P43346

• Rat Gene Id：
• 79127

• Rat Swiss Prot No：
• P48769

• 免疫原：
• Synthesized peptide derived from human DCK AA range: 62-112

• 特异性：
• This antibody detects endogenous levels of DCK at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 29kD

• 背景：
• Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:NTP + deoxycytidine = NDP + dCMP.,function:Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DCK/DGK family.,subunit:Homodimer.,

• 细胞定位：
• Nucleus .

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