• 靶点：
• NEUR3

• 简介：
• >>Other glycan degradation;>>Sphingolipid metabolism;>>Metabolic pathways

• 基因名称：
• NEU3

• 蛋白名称：
• NEUR3

• Human Swiss Prot No：
• Q9UQ49

• Mouse Gene Id：
• 50877

• Mouse Swiss Prot No：
• Q9JMH7

• Rat Gene Id：
• 117185

• Rat Swiss Prot No：
• Q99PW5

• 免疫原：
• Synthesized peptide derived from human NEUR3 AA range: 132-182

• 特异性：
• This antibody detects endogenous levels of NEUR3 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 47kD

• 背景：
• This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.,function:Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.,similarity:Belongs to the glycosyl hydrolase 33 family.,similarity:Contains 3 BNR repeats.,tissue specificity:Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.,

• 细胞定位：
• Cell membrane ; Peripheral membrane protein . Membrane, caveola . Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). .

• 组织表达：
• Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.

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