• 靶点：
• SPSY

• 简介：
• >>Cysteine and methionine metabolism;>>Arginine and proline metabolism;>>Glutathione metabolism;>>Metabolic pathways

• 基因名称：
• SMS

• 蛋白名称：
• SPSY

• Human Gene Id：
• 6611

• Human Swiss Prot No：
• P52788

• Mouse Gene Id：
• 20603

• Mouse Swiss Prot No：
• P97355

• 免疫原：
• Synthesized peptide derived from human SPSY AA range: 81-131

• 特异性：
• This antibody detects endogenous levels of SPSY at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 40kD

• 背景：
• This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],

• 功能：
• catalytic activity:S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.,disease:Defects in SMS are the cause of Snyder-Robinson syndrome (SRS) [MIM:309583]; also called X-linked mental retardation Snyder-Robinson type. SRS is characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.,domain:Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity.,function:Required for normal viability, growth and fertility.,pathway:Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.,similarity:Belongs to

• 细胞定位：
• cytosol,extracellular exosome,

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