• 靶点：
• ATG3

• 简介：
• >>Autophagy - other;>>Autophagy - animal;>>Kaposi sarcoma-associated herpesvirus infection

• 基因名称：
• ATG3 APG3 APG3L

• 蛋白名称：
• ATG3

• Human Gene Id：
• 64422

• Human Swiss Prot No：
• Q9NT62

• Mouse Gene Id：
• 67841

• Mouse Swiss Prot No：
• Q9CPX6

• Rat Gene Id：
• 171415

• Rat Swiss Prot No：
• Q6AZ50

• 免疫原：
• Synthesized peptide derived from human ATG3 AA range: 28-78

• 特异性：
• This antibody detects endogenous levels of ATG3 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 35kD

• 背景：
• This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

• 功能：
• function:GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG3 family.,subunit:Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.

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