• 靶点：
• VP37C

• 简介：
• >>Endocytosis

• 基因名称：
• VPS37C PML39

• 蛋白名称：
• VP37C

• Human Gene Id：
• 55048

• Human Swiss Prot No：
• A5D8V6

• Mouse Gene Id：
• 107305

• Mouse Swiss Prot No：
• Q8R105

• 免疫原：
• Synthesized peptide derived from human VP37C AA range: 220-270

• 特异性：
• This antibody detects endogenous levels of VP37C at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 39kD

• 背景：
• VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008],

• 功能：
• function:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.,similarity:Belongs to the VPS37 family.,similarity:Contains 1 VPS37 C-terminal domain.,subcellular location:Probably associates with membranes. Recruited to the plasma membrane by HIV-1.,subunit:Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, FAM125A and FAM125B. Interacts with HGS and STAM2. Interacts with CEP55.,

• 细胞定位：
• Late endosome membrane ; Peripheral membrane protein . Probably associates with membranes. Recruited to the plasma membrane by HIV-1.

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