• 靶点：
• K1C40

• 简介：
• >>Estrogen signaling pathway;>>Staphylococcus aureus infection

• 基因名称：
• KRT40 KA36

• 蛋白名称：
• K1C40

• Human Gene Id：
• 125115

• Human Swiss Prot No：
• Q6A162

• Mouse Gene Id：
• 406221

• Mouse Swiss Prot No：
• Q6IFX3

• Rat Gene Id：
• 287679

• Rat Swiss Prot No：
• Q6IFW2

• 免疫原：
• Synthesized peptide derived from human K1C40 AA range: 143-193

• 特异性：
• This antibody detects endogenous levels of K1C40 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 47kD

• 背景：
• This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009],

• 功能：
• developmental stage:During differentiation of the hair, it is one of the last keratins expressed.,function:May play a role in late hair differentiation.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).,

• 细胞定位：
• intermediate filament,

• 组织表达：
• Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).

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