• 靶点：
• GRHPR

• 简介：
• >>Glycine, serine and threonine metabolism;>>Pyruvate metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Metabolic pathways

• 基因名称：
• GRHPR GLXR MSTP035

• 蛋白名称：
• GRHPR

• Human Gene Id：
• 9380

• Human Swiss Prot No：
• Q9UBQ7

• Mouse Gene Id：
• 76238

• Mouse Swiss Prot No：
• Q91Z53

• 免疫原：
• Synthesized peptide derived from human GRHPR AA range: 151-201

• 特异性：
• This antibody detects endogenous levels of GRHPR at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 36kD

• 背景：
• This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Glycolate + NADP(+) = glyoxylate + NADPH.,disease:Defects in GRHPR are the cause of hyperoxaluria primary type II (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.,function:Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Monomer.,tissue specificity:Ubiquitous. Most abundantly expressed in the liver.,

• 细胞定位：
• cytoplasm,peroxisomal matrix,cytosol,extracellular exosome,

• 组织表达：
• Ubiquitous. Most abundantly expressed in the liver.

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