• 靶点：
• PURA1

• 简介：
• >>Purine metabolism;>>Alanine, aspartate and glutamate metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors

• 基因名称：
• ADSSL1 ADSS1

• 蛋白名称：
• PURA1

• Human Gene Id：
• 122622

• Human Swiss Prot No：
• Q8N142

• Mouse Gene Id：
• 11565

• Mouse Swiss Prot No：
• P28650

• 免疫原：
• Synthesized peptide derived from human PURA1 AA range: 14-64

• 特异性：
• This antibody detects endogenous levels of PURA1 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 50kD

• 背景：
• This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

• 功能：
• catalytic activity:GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.,cofactor:Binds 1 magnesium ion per subunit.,function:Plays an important role in the de novo pathway of purine nucleotide biosynthesis.,pathway:Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.,similarity:Belongs to the adenylosuccinate synthetase family.,subunit:Homodimer.,tissue specificity:Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.

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