• 靶点：
• FUT1

• 简介：
• >>Glycosphingolipid biosynthesis - lacto and neolacto series;>>Glycosphingolipid biosynthesis - globo and isoglobo series;>>Metabolic pathways

• 基因名称：
• FUT1 H HSC

• 蛋白名称：
• FUT1

• Human Gene Id：
• 2523

• Human Swiss Prot No：
• P19526

• Mouse Swiss Prot No：
• O09160

• Rat Gene Id：
• 81919

• Rat Swiss Prot No：
• Q10980

• 免疫原：
• Synthesized peptide derived from human FUT1 AA range: 150-200

• 特异性：
• This antibody detects endogenous levels of FUT1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 40kD

• 背景：
• This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016],

• 功能：
• catalytic activity:GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,function:Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.,miscellaneous:There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.,online information:Blood group antigen gene mutation database,online

• 细胞定位：
• Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Membrane-bound form in trans cisternae of Golgi. .

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