TPM4 rabbit pAb

    • 货号：YT6301
    • 应用：WB
    • 种属：Human;Mouse;Rat
      • 靶点：
      • TPM4
      • 简介：
      • >>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy
      • 基因名称：
      • TPM4
      • 蛋白名称：
      • TPM4
      • Human Gene Id：
      • 7171
      • Human Swiss Prot No：
      • P67936
      • Mouse Swiss Prot No：
      • Q6IRU2
      • 免疫原：
      • Synthesized peptide derived from human TPM4 AA range: 127-177
      • 特异性：
      • This antibody detects endogenous levels of TPM4 at Human/Mouse/Rat
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1：500-2000
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量：
      • 27kD
      • 背景：
      • This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
      • 功能：
      • domain:The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.,function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.,similarity:Belongs to the tropomyosin family.,subunit:Heterodimer of an alpha and a beta chain.,tissue specificity:Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hyp
      • 细胞定位：
      • Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .
      • 组织表达：
      • Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
      • 产品图片
      • Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night

      相关报价

      • 货号：
      • YT6301
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-09-05
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