• 靶点：
• AFG3L2

• 简介：
• >>Spinocerebellar ataxia

• 基因名称：
• AFG3L2

• 蛋白名称：
• AFG3L2

• Human Gene Id：
• 10939

• Human Swiss Prot No：
• Q9Y4W6

• Mouse Gene Id：
• 69597

• Mouse Swiss Prot No：
• Q8JZQ2

• 免疫原：
• Synthesized peptide derived from human AFG3L2. at AA range: 744-793

• 特异性：
• AFG3L2 Polyclonal Antibody detects endogenous levels of AFG3L2

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)

• 实测条带：
• 88kD

• 背景：
• This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008],

• 功能：
• cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Mitochondrion . Mitochondrion inner membrane ; Multi-pass membrane protein .

• 组织表达：
• Ubiquitous. Highly expressed in the cerebellar Purkinje cells.

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