• 靶点：
• ADI1

• 简介：
• >>Cysteine and methionine metabolism;>>Metabolic pathways

• 基因名称：
• ADI1 MTCBP1 HMFT1638

• 蛋白名称：
• 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding pro

• Human Gene Id：
• 55256

• Human Swiss Prot No：
• Q9BV57

• Mouse Gene Id：
• 104923

• Mouse Swiss Prot No：
• Q99JT9

• Rat Swiss Prot No：
• Q562C9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human ADI1. AA range:71-120

• 特异性：
• The antibody detects endogenous ADI1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54;Acireductone dioxygenase (Fe(2+)-requiring);ARD;Fe-ARD;Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;MTCBP-1;Submergence-induced protein-like factor;Sip-L)

• 背景：
• This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

• 功能：
• cofactor:Binds 1 nickel ion per monomer. Can also use other divalent metal cations.,function:Has aci-reductone dioxygenase (ARD) activity and can function in the 5-methylthioadenosine (MTA) methionine salvage pathway. Down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.,pathway:Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from (S)-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.,similarity:Belongs to the acireductone dioxygenase (ARD) family.,subunit:Interacts with MMP14.,tissue specificity:Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.,

• 细胞定位：
• Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to the plasma membrane when complexed to MMP14. .

• 组织表达：
• Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.

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