• 靶点：
• HSP 75

• 简介：
• >>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases

• 基因名称：
• TRAP1 HSP75

• 蛋白名称：
• Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)

• Human Gene Id：
• 10131

• Human Swiss Prot No：
• Q12931

• Mouse Gene Id：
• 68015

• Mouse Swiss Prot No：
• Q9CQN1

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human TRAP1. AA range:481-530

• 特异性：
• The antibody detects endogenous HSP 75

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Heat shock protein 75 kDa, mitochondrial (HSP 75;TNFR-associated protein 1;Tumor necrosis factor type 1 receptor-associated protein;TRAP-1)

• 背景：
• This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],

• 功能：
• function:Chaperone that expresses an ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subunit:Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1.,tissue specificity:Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.,

• 细胞定位：
• Mitochondrion . Mitochondrion inner membrane . Mitochondrion matrix .

• 组织表达：
• Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.

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