NNT-1 Polyclonal Antibody
- 货号:YT5957
- 应用:IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Cytokine-cytokine receptor interaction
- 基因名称:
- CLCF1 BSF3 CLC NNT1
- 蛋白名称:
- Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
- 免疫原:
- Synthetic peptide from human protein at AA range: 171-220
- 特异性:
- The antibody detects endogenous NNT-1
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1)
- 背景:
- This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin
- 功能:
- disease:Defects in CLCF1 are the cause of cold-induced sweating syndrome 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.,function:Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.,similarity:Belongs to the IL-6 superfamily.,tissue specificity:Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.,
- 组织表达:
- Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
![](/uploadfiles/PIC/yt5957ihc-human-brain2.jpg)
- Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200