CD236 Polyclonal Antibody
- 货号：YT5950
- 应用：IHC;IF;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)
- 免疫原：
- Synthetic peptide from human protein at AA range: 11-60
- 特异性：
- The antibody detects endogenous CD236
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Glycophorin-C (Glycoconnectin;Glycophorin-D;GPD;Glycoprotein beta;PAS-2';Sialoglycoprotein D;CD antigen CD236)
- 背景：
- Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012],
- 功能：
- function:This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin C plays an important role in regulating the stability of red cells.,online information:Blood group antigen gene mutation database,online information:Glycophorin C entry,polymorphism:GYPC is responsible for the Gerbich blood group system.,subcellular location:Linked to the membrane via Band 4.1.,tissue specificity:Glycophorin C is expressed in erythrocytes. Glycophorin D is ubiquitous.,
- 细胞定位：
- Cell membrane; Single-pass type III membrane protein. Linked to the membrane via band 4.1.
- 组织表达：
- Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
- Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
