CD300b Polyclonal Antibody

    • 货号:YT5949
    • 应用:IHC;IF;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • CD300b
      • 基因名称:
      • CD300LB CD300B CLM7 CMRF35A2 IREM3 LMIR5 TREM5 UNQ2530/PRO6029
      • 蛋白名称:
      • CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor express
      • Human Swiss Prot No:
      • A8K4G0
      • Mouse Swiss Prot No:
      • Q3U497
      • 免疫原:
      • Synthetic peptide from human protein at AA range: 61-110
      • 特异性:
      • The antibody detects endogenous CD300b
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • CMRF35-like molecule 7 (CLM-7;CD300 antigen-like family member B;CMRF35-A2;Immune receptor expressed on myeloid cells 3;IREM-3;Leukocyte mono-Ig-like receptor 5;Triggering receptor expressed on myeloid cells 5;TREM-5;CD antigen CD300b)
      • 背景:
      • CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008],
      • 功能:
      • function:Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitement of GRB2.,PTM:Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.,similarity:Belongs to the CD300 family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.,tissue specificity:Expressed exclusively in myeloid lineages.,
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein .
      • 组织表达:
      • Expressed exclusively in myeloid lineages.
      • 产品图片
      • Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:200