CD327 Polyclonal Antibody
- 货号:YT5945
- 应用:IHC;IF;ELISA
- 种属:Human
- 基因名称:
- SIGLEC6 CD33L CD33L1 OBBP1
- 蛋白名称:
- Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
- 免疫原:
- Synthetic peptide from human protein at AA range: 71-120
- 特异性:
- The antibody detects endogenous CD327
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Sialic acid-binding Ig-like lectin 6 (Siglec-6;CD33 antigen-like 1;CDw327;Obesity-binding protein 1;OB-BP1;CD antigen CD327)
- 背景:
- This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016],
- 功能:
- domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.,online information:Siglec-6,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with LEP.,tissue specificity:Expressed at high levels in placenta (cyto-and syncytiotrophob
- 细胞定位:
- [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
- 组织表达:
- Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
![](/uploadfiles/PIC/yt5945ihc-human-spleen.jpg)
- Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200