• 靶点：
• CD314

• 简介：
• >>Natural killer cell mediated cytotoxicity;>>Malaria

• 基因名称：
• KLRK1 D12S2489E NKG2D

• 蛋白名称：
• NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

• Human Gene Id：
• 22914

• Human Swiss Prot No：
• P26718

• Mouse Gene Id：
• 27007

• Mouse Swiss Prot No：
• O54709

• 免疫原：
• Synthetic peptide from human protein at AA range: 167-216

• 特异性：
• The antibody detects endogenous CD314

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1;NK cell receptor D;NKG2-D-activating NK receptor;CD antigen CD314)

• 背景：
• Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of

• 功能：
• alternative products:A number of isoforms are produced,function:Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.,miscellaneous:Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.,online information:NKG-2D,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.,tissue specificity:Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).

• 细胞定位：
• Cell membrane ; Single-pass type II membrane protein . Colocalized with HCST on the cell surface.

• 组织表达：
• Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).

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