Integrin α1 Polyclonal Antibody
- 货号:YT5908
- 应用:IHC;IF;ELISA
- 种属:Human;Rat;Mouse;
- 简介:
- >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Human papillomavirus infection;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- 蛋白名称:
- Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)
- 免疫原:
- Synthetic peptide from human protein at AA range: 920-980
- 特异性:
- The antibody detects endogenous Integrin α1
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Integrin alpha-1 (CD49 antigen-like family member A;Laminin and collagen receptor;VLA-1;CD antigen CD49a)
- 背景:
- integrin subunit alpha 1(ITGA1) Homo sapiens This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.,
- 细胞定位:
- Membrane; Single-pass type I membrane protein.
- 组织表达:
- Brain,Liver,Plasma,
![](/uploadfiles/PIC/yt5908ihc-human-colon-cancer.jpg)
- Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
![](/uploadfiles/PIC/yt5908ihc-human-lung-cancer.jpg)
- Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200