• 靶点：
• Integrin α1

• 简介：
• >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Human papillomavirus infection;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• ITGA1

• 蛋白名称：
• Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)

• Human Gene Id：
• 3672

• Human Swiss Prot No：
• P56199

• Mouse Gene Id：
• 109700

• Mouse Swiss Prot No：
• Q3V3R4

• 免疫原：
• Synthetic peptide from human protein at AA range: 920-980

• 特异性：
• The antibody detects endogenous Integrin α1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Integrin alpha-1 (CD49 antigen-like family member A;Laminin and collagen receptor;VLA-1;CD antigen CD49a)

• 背景：
• integrin subunit alpha 1(ITGA1) Homo sapiens This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.,

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Brain,Liver,Plasma,

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