• 靶点：
• I-FABP

• 简介：
• >>PPAR signaling pathway;>>Fat digestion and absorption

• 基因名称：
• FABP2 FABPI

• 蛋白名称：
• Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)

• Human Gene Id：
• 2169

• Human Swiss Prot No：
• P12104

• Mouse Gene Id：
• 14079

• Mouse Swiss Prot No：
• P55050

• Rat Swiss Prot No：
• P02693

• 免疫原：
• Synthetic peptide from human protein at AA range: 90-132

• 特异性：
• The antibody detects endogenous I-FABP

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2;Intestinal-type fatty acid-binding protein;I-FABP)

• 实测条带：
• 15kD

• 背景：
• The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008],

• 功能：
• domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,function:FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.,induction:By EGF.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.,

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.

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