• 靶点：
• Nodal

• 简介：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells

• 基因名称：
• NODAL

• 蛋白名称：
• Nodal homolog

• Human Gene Id：
• 4838

• Human Swiss Prot No：
• Q96S42

• Mouse Gene Id：
• 18119

• Mouse Swiss Prot No：
• P43021

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343

• 特异性：
• Nodal Polyclonal Antibody detects endogenous levels of Nodal protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NODAL;Nodal homolog

• 实测条带：
• 40kD

• 背景：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016],

• 功能：
• disease:Defects in NODAL may be a cause of situs ambiguus [MIM:601265].,function:Essential for mesoderm formation and axial patterning during embryonic development.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

• 细胞定位：
• Secreted .

• 组织表达：
• Brain cortex,Fetal brain,

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