• 靶点：
• Factor XIII B

• 简介：
• >>Complement and coagulation cascades;>>Coronavirus disease - COVID-19

• 基因名称：
• F13B

• 蛋白名称：
• Coagulation factor XIII B chain

• Human Gene Id：
• 2165

• Human Swiss Prot No：
• P05160

• Mouse Swiss Prot No：
• Q07968

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human F13B. AA range:500-550

• 特异性：
• Factor XIII B Polyclonal Antibody detects endogenous levels of Factor XIII B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• F13B;Coagulation factor XIII B chain;Fibrin-stabilizing factor B subunit;Protein-glutamine gamma-glutamyltransferase B chain;Transglutaminase B chain

• 实测条带：
• 65kD

• 背景：
• This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classi

• 功能：
• disease:Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,function:The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.,online information:Factor XIII entry,online information:The Singapore human mutation and polymorphism database,similarity:Contains 10 Sushi (CCP/SCR) domains.,subunit:Tetramer of two A chains and two B chains.,

• 细胞定位：
• Secreted .

• 组织表达：
• Heart,Liver,Plasma,

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