• 靶点：
• Dectin-2

• 简介：
• >>C-type lectin receptor signaling pathway

• 基因名称：
• CLEC6A

• 蛋白名称：
• C-type lectin domain family 6 member A

• Human Gene Id：
• 93978

• Human Swiss Prot No：
• Q6EIG7

• Mouse Swiss Prot No：
• Q9JKF4

• 免疫原：
• Synthesized peptide derived from the Internal region of human Dectin-2.

• 特异性：
• Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CLEC6A;CLECSF10;DECTIN2;C-type lectin domain family 6 member A;C-type lectin superfamily member 10;Dendritic cell-associated C-type lectin 2;DC-associated C-type lectin 2;Dectin-2

• 实测条带：
• 23kD

• 背景：
• The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

• 功能：
• function:May be involved in regulating immune reactivity.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in dendritic cells.,

• 细胞定位：
• Cell membrane ; Single-pass type II membrane protein .

• 组织表达：
• Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

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