• 靶点：
• ADAMTS-18

• 基因名称：
• ADAMTS18

• 蛋白名称：
• A disintegrin and metalloproteinase with thrombospondin motifs 18

• Human Gene Id：
• 170692

• Human Swiss Prot No：
• Q8TE60

• Mouse Gene Id：
• 208936

• Mouse Swiss Prot No：
• Q4VC17

• 免疫原：
• Synthesized peptide derived from ADAMTS-18 . at AA range: 1030-1110

• 特异性：
• ADAMTS-18 Polyclonal Antibody detects endogenous levels of ADAMTS-18 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ADAMTS18;ADAMTS21;A disintegrin and metalloproteinase with thrombospondin motifs 18;ADAM-TS 18;ADAM-TS18;ADAMTS-18

• 实测条带：
• 135kD

• 背景：
• This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016],

• 功能：
• cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.,

• 细胞定位：
• Secreted, extracellular space, extracellular matrix .

• 组织表达：
• Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.

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