• 靶点：
• CD244

• 简介：
• >>Natural killer cell mediated cytotoxicity

• 基因名称：
• CD244

• 蛋白名称：
• Natural killer cell receptor 2B4

• Human Gene Id：
• 51744

• Human Swiss Prot No：
• Q9BZW8

• Mouse Swiss Prot No：
• Q07763

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CD244. AA range:101-150

• 特异性：
• CD244 Polyclonal Antibody detects endogenous levels of CD244 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD244;2B4;Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NK cell type I receptor protein 2B4;NKR2B4;h2B4;CD244

• 实测条带：
• 42kD

• 背景：
• This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],

• 功能：
• function:Modulate other receptor-ligand interactions to enhance leukocyte activation.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.,tissue specificity:Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.,

• 细胞定位：
• Membrane ; Single-pass type I membrane protein . Cell membrane . Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. .

• 组织表达：
• Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed in all natural killer (NK) cells, monocytes and basophils, TCR-gamma/delta+ T-cells, monocytes, basophils, and on a subset of CD8(+) T-cells.

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