Nectin 1 Polyclonal Antibody
- 货号:YT5602
- 应用:WB;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Cell adhesion molecules;>>Adherens junction;>>Herpes simplex virus 1 infection
- 蛋白名称:
- Poliovirus receptor-related protein 1
- 免疫原:
- The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL1. AA range:81-130
- 特异性:
- Nectin 1 Polyclonal Antibody detects endogenous levels of Nectin 1 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- PVRL1;HVEC;PRR1;Poliovirus receptor-related protein 1;Herpes virus entry mediator C;Herpesvirus entry mediator C;HveC;Herpesvirus Ig-like receptor;HIgR;Nectin-1;CD111
- 背景:
- This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009],
- 功能:
- disease:Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.,disease:Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7) [MIM:225060]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cle
- 细胞定位:
- [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane .; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Gamma]: Secreted.
![](/uploadfiles/PIC/yt5602-wb.jpg)
- Western Blot analysis of KB cells using Nectin 1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
![](/uploadfiles/PIC/yt5602-wb(2).jpg)
- Western Blot analysis of KB cells using Nectin 1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000