• 靶点：
• M-CSF

• 简介：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>TNF signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Rheumatoid arthritis

• 基因名称：
• CSF1

• 蛋白名称：
• Macrophage colony-stimulating factor 1

• Human Gene Id：
• 1435

• Human Swiss Prot No：
• P09603

• Mouse Swiss Prot No：
• P07141

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human CSF1. AA range:505-554

• 特异性：
• M-CSF Polyclonal Antibody detects endogenous levels of M-CSF protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CSF1;Macrophage colony-stimulating factor 1;CSF-1;M-CSF;MCSF;Lanimostim

• 实测条带：
• 48kD

• 背景：
• The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],

• 功能：
• function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.,PTM:Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.,PTM:Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.,subunit:Homodimer or heterodimer; disulfide-linked.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein .; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.

• 组织表达：
• Endometrium,Kidney,Pancreatic carcinoma,T lymphoblast,Trophoblast,Urine,

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