• 靶点：
• OAS2

• 简介：
• >>NOD-like receptor signaling pathway;>>Hepatitis C;>>Measles;>>Influenza A;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19

• 基因名称：
• OAS2

• 蛋白名称：
• 2'-5'-oligoadenylate synthase 2

• Human Gene Id：
• 4939

• Human Swiss Prot No：
• P29728

• Mouse Gene Id：
• 246728

• Mouse Swiss Prot No：
• E9Q9A9

• Rat Gene Id：
• 363938

• Rat Swiss Prot No：
• Q5MYU0

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110

• 特异性：
• OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• OAS2;2'-5'-oligoadenylate synthase 2;(2-5')oligo(A) synthase 2;2-5A synthase 2;p69 OAS / p71 OAS;p69OAS / p71OAS

• 实测条带：
• 82kD

• 背景：
• 2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,

• 细胞定位：
• Cytoplasm . Cytoplasm, perinuclear region .

• 组织表达：
• Blood,Colon,Testis,Uterus,

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