• 靶点：
• LIR-7

• 简介：
• >>Osteoclast differentiation;>>B cell receptor signaling pathway

• 基因名称：
• LILRA2

• 蛋白名称：
• Leukocyte immunoglobulin-like receptor subfamily A member 2

• Human Gene Id：
• 11027

• Human Swiss Prot No：
• Q8N149

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human LILRA2. AA range:121-170

• 特异性：
• LIR-7 Polyclonal Antibody detects endogenous levels of LIR-7 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• LILRA2;ILT1;LIR7;Leukocyte immunoglobulin-like receptor subfamily A member 2;CD85 antigen-like family member H;Immunoglobulin-like transcript 1;ILT-1;Leukocyte immunoglobulin-like receptor 7;LIR-7;CD85h

• 实测条带：
• 53kD

• 背景：
• This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014],

• 功能：
• function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Secreted .

• 组织表达：
• Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level) (PubMed:12529506, PubMed:22479404). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455).

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