• 靶点：
• 17β-HSD4

• 简介：
• >>Primary bile acid biosynthesis;>>Biosynthesis of unsaturated fatty acids;>>Metabolic pathways;>>Fatty acid metabolism;>>Peroxisome

• 基因名称：
• HSD17B4

• 蛋白名称：
• Peroxisomal multifunctional enzyme type 2

• Human Gene Id：
• 3295

• Human Swiss Prot No：
• P51659

• Mouse Gene Id：
• 15488

• Mouse Swiss Prot No：
• P51660

• Rat Gene Id：
• 79244

• Rat Swiss Prot No：
• P97852

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human HSD17B4. AA range:41-90

• 特异性：
• 17β-HSD4 Polyclonal Antibody detects endogenous levels of 17β-HSD4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HSD17B4;EDH17B4;Peroxisomal multifunctional enzyme type 2;MFE-2;17-beta-hydroxysteroid dehydrogenase 4;17-beta-HSD 4;D-bifunctional protein;DBP;Multifunctional protein 2;MPF-2

• 实测条带：
• 80kD

• 背景：
• hydroxysteroid 17-beta dehydrogenase 4(HSD17B4) Homo sapiens The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

• 功能：
• catalytic activity:(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.,catalytic activity:(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.,disease:Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.,function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 1 SCP2 domain.,tissue specificity:Present in many tissues with highest concentrations in liver, heart, prostate and testis.,

• 细胞定位：
• Peroxisome .

• 组织表达：
• Present in many tissues with highest concentrations in liver, heart, prostate and testis.

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