• 靶点：
• HSP 90

• 简介：
• >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• 基因名称：
• HSP90AA1/HSP90AB1

• 蛋白名称：
• Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta

• Human Gene Id：
• 3326

• Human Swiss Prot No：
• P07900/P08238

• Mouse Gene Id：
• 15519/15516

• Mouse Swiss Prot No：
• P07901/P11499

• Rat Gene Id：
• 299331/301252

• Rat Swiss Prot No：
• P82995/P34058

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human HSP90A/B around the non-acetylation site of Lys292/284. AA range:251-300

• 特异性：
• HSP 90 Polyclonal Antibody detects endogenous levels of HSP 90 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HSP90AA1;HSP90A;HSPC1;HSPCA;Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38;HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84

• 实测条带：
• 85kD

• 背景：
• The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

• 功能：
• caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,

• 细胞定位：
• Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• 组织表达：
• Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius

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