CD207 Polyclonal Antibody
- 货号：YT5275
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- C-type lectin domain family 4 member K
- 免疫原：
- The antiserum was produced against synthesized peptide derived from the Internal region of human CD207. AA range:61-110
- 特异性：
- CD207 Polyclonal Antibody detects endogenous levels of CD207 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CD207;CLEC4K;C-type lectin domain family 4 member K;Langerin;CD207
- 背景：
- The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010],
- 功能：
- function:Calcium-dependent lectin displaying mannose-binding specificity, Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering.,online information:Langerin,similarity:Contains 1 C-type lectin domain.,subcellular location:Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.,tissue specificity:Exclusively expressed by Langerhans cells.,
- 细胞定位：
- Membrane ; Single-pass type II membrane protein . Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
- 组织表达：
- Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
- Western Blot analysis of K562 cells using CD207 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
- Western blot analysis of lysate from K562 cells, using CD207 Antibody.
