• 靶点：
• CD84

• 基因名称：
• CD84

• 蛋白名称：
• SLAM family member 5

• Human Gene Id：
• 8832

• Human Swiss Prot No：
• Q9UIB8

• Mouse Gene Id：
• 12523

• Mouse Swiss Prot No：
• Q18PI6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CD84. AA range:131-180

• 特异性：
• CD84 Polyclonal Antibody detects endogenous levels of CD84 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD84;SLAMF5;SLAM family member 5;Cell surface antigen MAX.3;Hly9-beta;Leukocyte differentiation antigen CD84;Signaling lymphocytic activation molecule 5;CD84

• 实测条带：
• 39kD

• 背景：
• This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],

• 功能：
• developmental stage:Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.,domain:ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.,function:Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.,PTM:N-glycosylated.,PTM:Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein .

• 组织表达：
• Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.

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