• 靶点：
• DPYD

• 简介：
• >>Pyrimidine metabolism;>>beta-Alanine metabolism;>>Pantothenate and CoA biosynthesis;>>Drug metabolism - other enzymes;>>Metabolic pathways

• 基因名称：
• DPYD

• 蛋白名称：
• Dihydropyrimidine dehydrogenase [NADP(+)]

• Human Gene Id：
• 1806

• Human Swiss Prot No：
• Q12882

• Mouse Gene Id：
• 99586

• Mouse Swiss Prot No：
• Q8CHR6

• Rat Gene Id：
• 81656

• Rat Swiss Prot No：
• O89000

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human DPYD. AA range:351-400

• 特异性：
• DPYD Polyclonal Antibody detects endogenous levels of DPYD protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DPYD;Dihydropyrimidine dehydrogenase [NADP(+)];DHPDHase;DPD;Dihydrothymine dehydrogenase;Dihydrouracil dehydrogenase

• 实测条带：
• 120kD

• 背景：
• The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],

• 功能：
• catalytic activity:5,6-dihydrouracil + NADP(+) = uracil + NADPH.,cofactor:Binds 2 4Fe-4S clusters. Contains approximately 33 iron atoms per molecule.,cofactor:Binds 2 FAD.,cofactor:Binds 2 FMN.,disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.,function:Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

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