Protein C Polyclonal Antibody
- 货号：YT5221
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>Complement and coagulation cascades
- 蛋白名称：
- Vitamin K-dependent protein C
- 免疫原：
- The antiserum was produced against synthesized peptide derived from the Internal region of human PROC. AA range:181-230
- 特异性：
- Protein C Polyclonal Antibody detects endogenous levels of Protein C protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- PROC;Vitamin K-dependent protein C;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV
- 背景：
- This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009],
- 功能：
- catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form l
- 细胞定位：
- Secreted . Golgi apparatus . Endoplasmic reticulum .
- 组织表达：
- Plasma; synthesized in the liver.
- Western Blot analysis of K562 cells using Protein C Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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- Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100
- Western blot analysis of lysate from K562 cells, using PROC Antibody.
