• 靶点：
• FAF1

• 简介：
• >>Necroptosis

• 基因名称：
• FAF1

• 蛋白名称：
• FAS-associated factor 1

• Human Gene Id：
• 11124

• Human Swiss Prot No：
• Q9UNN5

• Mouse Gene Id：
• 14084

• Mouse Swiss Prot No：
• P54731

• Rat Gene Id：
• 140657

• Rat Swiss Prot No：
• Q924K2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human FAF1. AA range:461-510

• 特异性：
• FAF1 Polyclonal Antibody detects endogenous levels of FAF1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FAF1;UBXD12;UBXN3A;CGI-03;FAS-associated factor 1;hFAF1;UBX domain-containing protein 12;UBX domain-containing protein 3A

• 实测条带：
• 75kD

• 背景：
• Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008],

• 功能：
• function:Potentiates but cannot initiate FAS-induced apoptosis.,similarity:Contains 1 UBX domain.,subunit:Specifically interacts with the cytoplasmic domain of FAS.,tissue specificity:Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

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