• 靶点：
• UBE2A/B

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• UBE2A/UBE2B

• 蛋白名称：
• Ubiquitin-conjugating enzyme E2 A/Ubiquitin-conjugating enzyme E2 B

• Human Gene Id：
• 7320

• Human Swiss Prot No：
• P49459/P63146

• Rat Gene Id：
• 81816

• Rat Swiss Prot No：
• P63149

• 免疫原：
• Synthesized peptide derived from the C-terminal region of human UBE2A/B.

• 特异性：
• UBE2A/B Polyclonal Antibody detects endogenous levels of UBE2A/B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UBE2A;RAD6A;Ubiquitin-conjugating enzyme E2 A;RAD6 homolog A;HR6A;hHR6A;Ubiquitin carrier protein A;Ubiquitin-protein ligase A;UBE2B;RAD6B;Ubiquitin-conjugating enzyme E2 B;RAD6 homolog B;HR6B;hHR6B;Ubiquitin carrier protein B;Ubiquitin-conjugating enzyme E2-17 kDa;Ubiquitin-protein ligase B

• 实测条带：
• 17kD

• 背景：
• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

• 功能：
• catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with RAD18.,

• 细胞定位：
• chromatin,nuclear chromatin,XY body,cytoplasm,cytosol,HULC complex,

• 组织表达：
• Lung,Skin,Subthalamic nucleus,Thyroid,

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