• 靶点：
• UBE4A

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• UBE4A

• 蛋白名称：
• Ubiquitin conjugation factor E4 A

• Human Gene Id：
• 9354

• Human Swiss Prot No：
• Q14139

• Rat Gene Id：
• 315608

• Rat Swiss Prot No：
• Q6P7A2

• 免疫原：
• Synthesized peptide derived from the N-terminal region of human UBE4A.

• 特异性：
• UBE4A Polyclonal Antibody detects endogenous levels of UBE4A protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UBE4A;KIAA0126;Ubiquitin conjugation factor E4 A

• 实测条带：
• 122kD

• 背景：
• This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011],

• 功能：
• function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Bone marrow,Platelet,Skeletal muscle,

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