BAGE5 Polyclonal Antibody
- 货号：YT5061
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 蛋白名称：
- BAG family molecular chaperone regulator 5
- 免疫原：
- Synthesized peptide derived from BAGE5 . at AA range: 30-110
- 特异性：
- BAGE5 Polyclonal Antibody detects endogenous levels of BAGE5 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- BAG5;KIAA0873;BAG family molecular chaperone regulator 5;BAG-5;Bcl-2-associated athanogene 5
- 背景：
- The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- 功能：
- function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2.,similarity:Contains 4 BAG domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2.,
- 细胞定位：
- nucleus,mitochondrion,cytosol,membrane,inclusion body,perinuclear region of cytoplasm,
- Western Blot analysis of extracts from Jurkat, K562 cells, using BAGE5 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
