• 靶点：
• Gl Syn

• 简介：
• >>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Nitrogen metabolism;>>Metabolic pathways;>>Biosynthesis of amino acids;>>Necroptosis;>>Glutamatergic synapse;>>GABAergic synapse

• 基因名称：
• GLUL

• 蛋白名称：
• Glutamine synthetase

• Human Gene Id：
• 2752

• Human Swiss Prot No：
• P15104

• Mouse Gene Id：
• 14645

• Mouse Swiss Prot No：
• P15105

• Rat Gene Id：
• 24957

• Rat Swiss Prot No：
• P09606

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Gl Syn. AA range:295-344

• 特异性：
• Gl Syn Polyclonal Antibody detects endogenous levels of Gl Syn protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GLUL;GLNS;Glutamine synthetase;GS;Glutamate decarboxylase;Glutamate--ammonia ligase

• 实测条带：
• 42kD

• 背景：
• The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

• 功能：
• catalytic activity:ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.,disease:Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.,online information:Glutamine synthetase entry,similarity:Belongs to the glutamine synthetase family.,subunit:Homooctamer.,

• 细胞定位：
• Cytoplasm, cytosol . Microsome . Mitochondrion . Cell membrane ; Lipid-anchor . Mainly localizes in the cytosol, with a fraction associated with the cell membrane. .

• 组织表达：
• Expressed in endothelial cells.

Butyrate Alleviates High-Fat-Induced Metabolic Disorders Partially through Increasing Systematic Glutamine JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Zeyu Fan WB Mouse 1:1000 epididymal white adipose tissue (eWAT),muscle tissue,liver tissue
货号：YT5035

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