EphA2/5 Polyclonal Antibody

  • 货号:YT5019
  • 应用:WB,ELISA
  • 种属:Human,Mouse
    • 基因名称:
    • EPHA2/EPHA5
    • 蛋白名称:
    • Ephrin type-A receptor 2/5
    • 免疫原:
    • Synthesized peptide derived from EphA2/5 . at AA range: 530-610
    • 特异性:
    • EphA2/5 Polyclonal Antibody detects endogenous levels of EphA2/5 protein.
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Rabbit
    • 稀释:
    • Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA5; BSK; EHK1; HEK7; TYRO4; Ephrin type-A receptor 5; Brain-specific kinase; EPH homology kinase 1; EHK-1; EPH-like kinase 7; EK7; hEK7
    • 分子量:
    • 108266
    • 实测条带:
    • 110
    • 背景:
    • EPH receptor A2(EPHA2) Homo sapiens This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010],
    • 功能:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with SLA (By similarity). Interacts with INPPL1/SHIP2.,tissue specificity:Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.,
    • 细胞定位:
    • intracellular,plasma membrane,integral component of plasma membrane,cell-cell adherens junction,focal adhesion,cell surface,lamellipodium,leading edge membrane,lamellipodium membrane,ruffle membrane,
    • 组织表达:
    • Colon,Epithelium,Liver,Pancreas,