• 靶点：
• X11β

• 基因名称：
• APBA2

• 蛋白名称：
• Amyloid beta A4 precursor protein-binding family A member 2

• Human Gene Id：
• 321

• Human Swiss Prot No：
• Q99767

• Mouse Gene Id：
• 11784

• Mouse Swiss Prot No：
• P98084

• Rat Gene Id：
• 83610

• Rat Swiss Prot No：
• O35431

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human APBA2. AA range:371-420

• 特异性：
• X11β Polyclonal Antibody detects endogenous levels of X11β protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• APBA2;MINT2;X11L;Amyloid beta A4 precursor protein-binding family A member 2;Adapter protein X11beta;Neuron-specific X11L protein;Neuronal Munc18-1-interacting protein 2;Mint-2

• 实测条带：
• 83kD

• 背景：
• amyloid beta precursor protein binding family A member 2(APBA2) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• domain:Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the amino-terminal domain of APBA2BP.,tissue specificity:Brain.,

• 细胞定位：
• plasma membrane,synaptic vesicle,

• 组织表达：
• Brain.

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